In this episode, Kellen speaks with Dr. Mitchell Kronenberg. Mitch is the chief scientific officer of the La Jolla Institute for Immunology, an adjunct professor at UC San Diego, and the co-director of a collaborative effort between the La Jolla Institute and UC San Diego called the Program in Immunology. Mitch and Kellen talk about unconventional T cells, autoimmunity, barrier immunity, chimeric antigen receptor (CAR) T cells, and the future of immunology. They also discuss Mitch’s philosophies related to science, mentorship, and life.

Recent Kronenberg lab paper with intravital microscopy: https://pubmed.ncbi.nlm.nih.gov/35905286/

Kronenberg lab website: https://www.lji.org/labs/kronenberg/

Mitch’s Wikipedia page: https://en.wikipedia.org/wiki/Mitchell_Kronenberg

Correction: When Kellen mentioned the published CAR T trial in human autoimmunity, he misspoke and said multiple sclerosis (MS) but the trial he was referring to was in patients with lupus. That said, published preclinical data suggests CAR T therapy may also work in MS patients.

CAR T cell therapy in patients with lupus: https://pubmed.ncbi.nlm.nih.gov/36109639/

CAR T cell therapy in MS mouse model: https://pubmed.ncbi.nlm.nih.gov/36206355/

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