Discoverthe bioinformatics chat#56 Polygenic risk scores in admixed populations with Bárbara Bitarello
#56 Polygenic risk scores in admixed populations with Bárbara Bitarello

#56 Polygenic risk scores in admixed populations with Bárbara Bitarello

Update: 2021-02-172
Share

Description

Polygenic risk scores (PRS) rely on the genome-wide association studies (GWAS)
to predict the phenotype based on the genotype. However, the prediction
accuracy suffers when GWAS from one population are used to calculate PRS within
a different population, which is a problem because the majority of the GWAS
are done on cohorts of European ancestry.



In this episode, Bárbara Bitarello helps us
understand how PRS work and why they don’t transfer well across populations.






Links:








If you enjoyed this episode, please consider supporting the podcast on Patreon.

Comments 
In Channel
loading
00:00
00:00
x

0.5x

0.8x

1.0x

1.25x

1.5x

2.0x

3.0x

Sleep Timer

Off

End of Episode

5 Minutes

10 Minutes

15 Minutes

30 Minutes

45 Minutes

60 Minutes

120 Minutes

#56 Polygenic risk scores in admixed populations with Bárbara Bitarello

#56 Polygenic risk scores in admixed populations with Bárbara Bitarello

Roman Cheplyaka