Send us a message with this link, we would love to hear from you. Standard message rates may apply.

We break down the key differences between Tylenol (acetaminophen) and NSAIDs (ibuprofen, naproxen, aspirin) to help you make informed decisions about which pain reliever is right for you. This evidence-based discussion draws from top medical sources to explain how these common medications work differently in your body.

• Tylenol works on perception of pain and fever in the brain but doesn't address inflammation
• NSAIDs reduce pain, fever AND inflammation by blocking the prostaglandin cascade
• Both medications are commonly used for everyday pain including headaches and general discomfort
• NSAIDs are usually more effective for inflammatory conditions like sprains, arthritis, and period cramps
• Tylenol's main risk is liver damage at high doses (max 4,000mg daily for most adults)
• NSAIDs can cause stomach ulcers, GI bleeding, increased blood pressure, and kidney problems
• Consider your medical history when choosing—liver issues (caution with Tylenol), stomach/heart/kidney problems (caution with NSAIDs)
• Age is a factor—older adults generally face higher risks with NSAIDs
• Taking NSAIDs with food can help reduce stomach problems
• Always read labels and follow dosing instructions carefully

Share this episode with friends or family who take these medications regularly to help them understand what they're putting in their bodies.

Support the show

Subscribe to Our Newsletter!

Production and Content: Edward Delesky, MD & Nicole Aruffo, RN
Artwork: Olivia Pawlowski