DiscoverIDBR Infectious Disease Board ReviewA confusing HIV serology - Trip Gulick, MD/ Frank Maldarelli, MD
A confusing HIV serology - Trip Gulick, MD/ Frank Maldarelli, MD

A confusing HIV serology - Trip Gulick, MD/ Frank Maldarelli, MD

Update: 2024-06-16
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Description

A 37-year-old woman from New Jersey undergoes routine HIV testing with the following results:


• HIV 4th generation test: Reactive (antibody positive + p24 antigen negative)


• HIV-1/2 Supplemental Assay: HIV-1 antibody negative, HIV-2 antibody negative


• HIV-1 RNA: <20 copies/ml


What is the most likely interpretation of the results?


A. She is a long-term non-progressor


B. She has acute HIV-1 infection


C. She has acute HIV-2 infection


D. She has a false negative viral test


E. She has a false positive 4th generation test




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A confusing HIV serology - Trip Gulick, MD/ Frank Maldarelli, MD

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