The first episode of the SOS AMS podcast focuses on general clinical topics in AMS, such as discerning when a patient has improved clinically and is appropriate for stepdown to an oral antibiotic, and developing a differential diagnosis for perceived non-response to antibiotics. Our hosts Julia and Nicki explore key clinical features and patterns for distinguishing antibiotic failure from a source control issue or from a non-infectious mimicker of infection in patients who are not responding to antibiotics. The principles discussed are applied to two patient cases at the end of the podcast. Relevant references can always accessed through the provided hyperlink. 

The learning objectives for this podcast are:

1. Identify which clinical features generally point to safe oral stepdown for patients with infections


2. Compare the clinical features that point to antibiotic failure vs. source control issue vs non-infectious mimicker in a patient with apparent antibiotic non-response


3. Apply knowledge of these principles to 2 patient cases.

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