Can Christians drink alcohol and smoke marijuana? This biblical analysis explores what Scripture actually teaches about substance use for believers. Many Christians wonder about alcohol consumption, especially since Jesus himself drank wine and performed his first miracle turning water into wine. The Bible warns against alcohol abuse, not use, providing three key principles for Christian drinking: legality, mental alertness, and love for others. When these conditions are met, believers can consume alcohol while maintaining full mental clarity and honoring God. However, marijuana presents different biblical challenges. THC affects brain receptors, impairing memory, attention, and motivation - directly contradicting Scripture's call for believers to be alert and sober-minded. Unlike alcohol, marijuana's recreational purpose is specifically to compromise mental alertness, making it incompatible with biblical standards for Christian living. This comprehensive biblical perspective addresses common questions about substance use, providing practical guidance for believers navigating these complex cultural issues. Topics covered include Jesus and wine, biblical principles for alcohol consumption, marijuana's effects on mental alertness, medical marijuana considerations, and God's grace for those struggling with substance use. Whether you're seeking clarity on Christian freedom, biblical sobriety, or substance use guidelines, this biblical analysis provides scriptural answers for modern believers facing these challenging decisions in contemporary culture.