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Aliquot #133: The Surprising Effects of Creatine on the Brain

Aliquot #133: The Surprising Effects of Creatine on the Brain

Update: 2025-08-15
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Creatine plays a key role in maintaining cellular energy balance, and evidence suggests it can help the brain meet its high energy demands more efficiently. In Aliquot #131, The Muscle and Bone Benefits of Creatine, creatine expert Dr. Darren Candow and I discussed how creatine supplementation affects muscle quality, physical function, and even skeletal health, particularly in older adults.

In Part II of this three-part series, Dr. Candow and I will cover the incredible brain benefits of creatine, especially in the settings of stress, aging, trauma, neurodegenerative disease, and more.

This episode includes several key discussion points:
  • 00:01:27 - How stress affects brain creatine
  • 00:03:31 - How much creatine increases brain levels?
  • 00:06:28 - Achieving brain benefits without bloating
  • 00:08:20 - Improving cognition during stress and sleep loss
  • 00:11:54 - Does creatine aid recovery from traumatic brain injury?
  • 00:13:07 - How much is enough for both brain and body?
  • 00:15:40 - Why creatine may help you sleep better after training
  • 00:19:09 - Can creatine help in neurodegenerative disease?
  • 00:20:43 - Supporting recovery from depression with creatine
This Aliquot features segments from the following episode:

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Aliquot #133: The Surprising Effects of Creatine on the Brain

Aliquot #133: The Surprising Effects of Creatine on the Brain

Rhonda Patrick, Ph.D.