Anaphylactic shock is a severe, life-threatening form of distributive shock caused by systemic hypersensitivity reactions and massive release of vasoactive mediators. It is characterized by hypotension, airway compromise, bronchospasm, and cutaneous findings such as urticaria and angioedema.

In this episode, we break down the pathophysiology of anaphylactic shock, classic clinical presentation, key hemodynamic patterns, and evidence-based management. We focus on early recognition, the critical role of intramuscular epinephrine, airway management, fluid resuscitation, and treatment of refractory shock.

We also review how to differentiate anaphylaxis from septic and neurogenic shock, discuss adjunctive therapies, and highlight major guideline recommendations from WAO, AAAAI, and NIAID/FAAN.

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Playlist on Shock: https://youtube.com/playlist?list=PLf5bMa9_tvRjunk4I-rQZYPZn3qHqWFqW&si=kserFPPm7RYuhul-

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