Welcome to Cardiology Today – Recorded September 05, 2025. This episode summarizes 2 key cardiology studies on topics like Clinical Trials and Protein Phosphatase 5. Key takeaway: Arachidonic Acid Drives Post-Infarct Inflammation.

Article Links:

Article 1: Arachidonic acid fuels inflammation by unlocking macrophage protein phosphatase 5 after myocardial infarction. (European heart journal)

Article 2: Decline in glomerular filtration rate as an endpoint in heart failure clinical trials: challenges and solutions. (European heart journal)

Full episode page: https://podcast.explainheart.com/podcast/arachidonic-acid-drives-post-infarct-inflammation-09-05-25/

Featured Articles

Article 1: Arachidonic acid fuels inflammation by unlocking macrophage protein phosphatase 5 after myocardial infarction.

Journal: European heart journal

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40905492

Summary: This study found that arachidonic acid, a polyunsaturated fatty acid metabolite, plays a critical role in driving post myocardial infarction inflammation by activating macrophage protein phosphatase 5. Single cell RNA sequencing revealed cardiac macrophage heterogeneity after myocardial infarction in mice and metabolomic analysis profiled polyunsaturated fatty acid metabolites in both mice and human patients. These findings suggest that targeting the arachidonic acid metabolic cascade could offer a novel therapeutic approach to modulate inflammation and improve cardiac repair after myocardial infarction.

Article 2: Decline in glomerular filtration rate as an endpoint in heart failure clinical trials: challenges and solutions.

Journal: European heart journal

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40905476

Summary: This article discusses the challenges and potential solutions for using decline in glomerular filtration rate as an endpoint in Heart Failure clinical trials, highlighting the interconnectedness of chronic kidney disease and cardiovascular disease. It addresses the importance of understanding how to best assess chronic kidney disease progression in the context of Heart Failure, given the increasing evidence for common therapies in both disease states and the cardiorenal metabolic syndrome framework. The piece is a review and perspective offering guidance for clinicians and regulatory agencies.

Transcript

Today’s date is September 05, 2025. Welcome to Cardiology Today. Here are the latest research findings.

Article number one. Arachidonic acid fuels inflammation by unlocking macrophage protein phosphatase 5 after myocardial infarction. This study found that arachidonic acid, a polyunsaturated fatty acid metabolite, plays a critical role in driving post myocardial infarction inflammation by activating macrophage protein phosphatase 5. Single cell RNA sequencing revealed cardiac macrophage heterogeneity after myocardial infarction in mice and metabolomic analysis profiled polyunsaturated fatty acid metabolites in both mice and human patients. These findings suggest that targeting the arachidonic acid metabolic cascade could offer a novel therapeutic approach to modulate inflammation and improve cardiac repair after myocardial infarction.

Article number two. Decline in glomerular filtration rate as an endpoint in heart failure clinical trials: challenges and solutions. This article discusses the challenges and potential solutions for using decline in glomerular filtration rate as an endpoint in Heart Failure clinical trials, highlighting the interconnectedness of chronic kidney disease and cardiovascular disease. It addresses the importance of understanding how to best assess chronic kidney disease progression in the context of Heart Failure, given the increasing evidence for common therapies in both disease states and the cardiorenal metabolic syndrome framework. The piece is a review and perspective offering guidance for clinicians and regulatory agencies.

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Keywords

Clinical Trials, Protein Phosphatase 5, Arachidonic Acid, Heart Failure, Macrophages, Myocardial Infarction, Cardiorenal Metabolic Syndrome, Inflammation, Chronic Kidney Disease, Glomerular Filtration Rate.

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