Butyrate — The Metabolic Powerhouse Fueling the Gut and Beyond
Update: 2025-12-22
Description
- Butyrate, a short-chain fatty acid produced by gut bacteria that ferment dietary fiber, helps improve metabolic health by enhancing insulin function, regulating glucose levels and supporting healthy body composition
- Unlike most cells that use glucose, colonocytes (the epithelial cells that line your colon) prefer butyrate for energy, converting 70% to 80% through beta-oxidation to maintain gut barrier health
- Promoting butyrate production through fiber intake is beneficial, but only if your gut is healthy. If your gut is compromised, starting with dextrose water before transitioning to whole foods is recommended
- Lifestyle factors significantly impact butyrate production, with chronic stress, smoking, excessive drinking and antibiotic overuse reducing beneficial gut bacteria and SCFA production
- Excessive linoleic acid consumption, common in processed foods and vegetable oils, reduce beneficial gut bacteria, negatively affecting gut and metabolic health
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