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Dosage and Administration:

1. Individualized Treatment:

Tramadol dosage is individualized based on factors such as the severity of pain, the patient's response to opioids, and any pre-existing medical conditions. The goal is to provide effective pain relief while minimizing the risk of side effects.

2. Immediate Release vs. Extended Release:

Tramadol is available in both immediate-release (IR) and extended-release (ER) formulations. Immediate-release tramadol is suitable for managing acute pain, while extended-release formulations provide around-the-clock pain control for chronic conditions.

3. Caution with Ultrarapid Metabolizers:

Careful consideration is necessary for individuals who are ultrarapid metabolizers due to genetic factors. The rapid conversion of tramadol to its active metabolite may necessitate dose adjustments or alternative analgesic options.