Traumatic brain injury (TBI) can lead to significant behavioral changes due to damage to the frontal lobe, disruption of neurotransmitters like serotonin and dopamine, and impaired communication between brain regions. These factors can cause a range of symptoms, including disinhibition, poor judgment, irritability, aggression, lack of empathy, emotional dysregulation, depression, anxiety, and agitation. People with a history of psychiatric disorders, substance abuse, or previous brain injuries are more susceptible to behavioral problems after TBI. Understanding the neurological basis of these changes is crucial for developing effective treatment and support strategies for patients and families.