Chromosomal instability
Update: 2023-03-22
Description
In this week's episode, Professor Florian Markowetz talks about his work and recent publication on chromosomal instability. Chromosomal instability is a dynamic process of DNA change, which leads to some DNA being present multiple times and some being lost altogether. Some cancers are dominated by this process of genomic disruption; ovarian, pancreatic and triple-negative breast cancer for example. These chaotic DNA changes mean that there are not good biomarkers present to guide treatment decisions. Florian's laboratory has found a structure underlying chromosomal instability and has identified genomic fingerprints which enable them to read out the fundamental reasons for the DNA changes.
Florian is a group leader at the Cancer Research UK Cambridge Institute at the University of Cambridge, UK.
Florian is a group leader at the Cancer Research UK Cambridge Institute at the University of Cambridge, UK.
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