Conférence - Emmanuelle Passegué : Hematopoietic Stem Cell Aging and Adaptation to Stress
Description
Hugues de Thé
Collège de France
Oncologie cellulaire et moléculaire
Année 2025-2026
Hematopoietic Stem Cell Aging and Adaptation to Stress
Conférence - Emmanuelle Passegué : Adaptive and Maladaptive Myeloid Cell Production
Emmanuelle Passegué
Directrice de la Columbia Stem Cell Initiative et professeure émérite de génétique et de développement à l'université Columbia
Résumé
Although young adult HSCs employ finely tuned mechanisms to balance pro-survival and stress responses, these maintenance strategies provoke vulnerabilities that manifest with continued age, leading to a decline in function. We will examine HSC biology through the lens of antagonistic pleiotropy, whereby the same mechanisms that are important for reproductive fitness form the basis for functional decline during aging. We will particularly highlight the central role of cell cycle regulation, niche cell reliance, inflammatory responses, cellular memory, and distinct metabolic regulation in driving HSC aging features, including expansion of the HSC pool, decreased self-renewal ability, myeloid-biased differentiation, and genomic instability leading to clonal hematopoiesis (CH) and leukemic transformation.
United States
