Difluorinated Alkyl Bromide Synthesis via Chiral Iodoarene Catalysis

Update: 2020-11-30

Description

In this episode we discuss a report from the Jacobsen lab on an enantioselective synthesis of difluorinated alkyl bromides catalyzed by a chiral iodoarene. Linear free energy relationships between experimental enantioselectivities and computed catalyst parameters helped elucidate the origins of enantioselectivity.

DOI: 10.1021/jacs.0c07043

Comments

In Channel

Asymmetric Hydroamination

2020-12-2136:01

Mark Levin Interview

2020-12-0743:52

Difluorinated Alkyl Bromide Synthesis via Chiral Iodoarene Catalysis

2020-11-3030:11

Marshall Brennan Interview

2020-11-1653:35

Daniele Leonori Interview

2020-10-1936:41

Dehydrogenative Aniline Synthesis

2020-10-1235:29

M. Christina White Interview

2020-09-2855:22

Late-Stage C–H Methylation

2020-09-2134:54

Total Synthesis of Maximiscin

2020-09-0737:20

Jake Yeston

2019-11-0445:18

Total Synthesis of Perseanol

2019-10-0723:30

Silver-Catalysed Nitrene Transfer

2019-09-2326:17

Organocatalytic Mitsunobu Reactions

2019-09-0924:03

Thianthrenium Salts as New Synthetic Linchpin

2019-08-2621:26

Electrophotocatalytic C-H Oxidation

2019-08-0518:07

Total Synthesis of Arcutinidine

2019-07-2219:40

Derivatizing Chiral Phosphorothioate Salts

2019-07-0823:11

Cleaving Olefins through Hydrodealkenylation

2019-06-2424:21

Photochemical C-H Amination through in situ N-Chloroamines - Leonori

2019-06-1025:00

Trailer

2019-05-2902:00

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Difluorinated Alkyl Bromide Synthesis via Chiral Iodoarene Catalysis

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Difluorinated Alkyl Bromide Synthesis via Chiral Iodoarene Catalysis

Matthew Genzink

Difluorinated Alkyl Bromide Synthesis via Chiral Iodoarene Catalysis