Welcome to episode 5 of the insulin360 podcast where we talking about autophagy and metabolid health. My guest today is Nic Verhoeven, a cell and molecular biology researcher who is currently working towards his doctorate in molecular medicine in a lab focusing on autophagy. We talk what autophagy is, the different types of autophagy, how it's dysfunction can lead to poor health and disease and what we can do to optimise it such as diet, fasting and exercise. We also get into dietary fats and their effects on insulin signalling.

Be sure to check Nic's site out at www.physionic.org or follow him on Youtube @Physionic.

Sections:

2:50 Nic's day job in the lab 4:30 Definition of autophagy 8:14 What triggers autophagy 11:30 AMPK the master switch 14:06 How does autophagy dysfunction lead to chronic disease 21:15 Overnutrition and mTOR activation 25:15 Circadian rhythms 27:12 Cortisol and chronic stress 30:35 How long to fast to trigger autophagy? 33:30 Different tissue considerations 38:50 Measuring autophagy in the future? 42:45 Different types of fasting and their benefits 48:55 Saturated fats and their effects on insulin signalling 55:40 Ceramides and insulin signalling inhibition 1:04:50 the 80/20 rule and finding balance 1:16:16 Next steps for Nic

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