為何有些上皮性卵巢癌細胞能逃過化療？一項發表在《細胞與分子醫學》期刊的研究揭示，一種名為 PEO 的特定脂質分子，特別是透過細胞內 AGPS 酵素合成的這類 PEO，就像為癌細胞穿上了一層「保護罩」。研究人員分析大型資料庫 (如 CCLEC, GDSC) 與實驗室數據，發現甘油磷脂代謝，尤其是 PEO 的含量，與癌細胞對常用化療藥物 紫杉醇 (Paclitaxel) 和 鉑類藥物 (Cisplatin) 的不敏感性有顯著的正相關。透過補充 PEO、抑制 AGPS 等實驗，證實細胞自身合成的 PEO 是導致抗藥性的關鍵因素。本集將深入解析這個「脂質防護罩」的秘密，以及它如何影響癌症治療效果。
Why do some epithelial ovariancancer cells evade chemotherapy? A study published in the journal Cell & Molecular Medicine reveals that a specific lipid molecule called PEO,particularly the type synthesized by the intracellular enzyme AGPS, acts like a "protective shield" for cancer cells. Researchers analyzed large databases (like CCLEC, GDSC) and lab data, finding a significant positivecorrelation between glycerol phospholipid metabolism, especially the level of PEO, and the insensitivity of cancer cells to common chemotherapy drugs like Paclitaxel and Cisplatin. Experiments involving PEO supplementation and AGPS inhibition confirmed that PEO synthesized internally by the cell is a key factor in causing drug resistance. This episode delves into the secret of this "lipid shield" and how it impacts the effectiveness of cancer treatment.-

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