Ep. 172 VEXAS: A Mystery Syndrome
Update: 2023-02-22
Description
While science and medicine have come a long way over the centuries, there are still illnesses that cannot be explained -- and many of them are autoinflammatory disorders. Many people all over the world have been inflicted with these disorders with no clear cause.
But recently, scientists were able to find a mutation that can help explain what some of these people are going through, a mutation that led to the identification of an autoinflammatory disorder now known as VEXAS. Tune in to learn more!
References:
- https://www.nejm.org/doi/full/10.1056/nejmoa2026834
- https://www.nature.com/articles/nrm.2017.83
- https://www.sciencedirect.com/science/article/pii/S0962892413002274
- https://www.sciencedirect.com/science/article/pii/S0006497121010223
- https://journals.physiology.org/doi/abs/10.1152/physrev.00004.2022
- https://www.niams.nih.gov/labs/grayson-lab/vexas
- https://jamanetwork.com/journals/jama/article-abstract/2800661
- https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.17893
- https://www.nature.com/articles/s41375-022-01698-8
- https://ashpublications.org/blood/article-abstract/140/8/927/485331/Ruxolitinib-is-more-effective-than-other-JAK
- https://ashpublications.org/bloodadvances/article/6/3/998/477726/Successful-allogeneic-hematopoietic-stem-cell
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