They have enjoyed great success since the 1980s with various artists, most notably Janet Jackson.They have written 31 top ten hits in the UK and 41 in the US.In 2022, the duo were inducted into the Rock and Roll Hall of Fame in the Musical Excellence category.

In an illustrious career that has spanned more than three decades, Jam and Lewis have worked with artists such as Lionel Richie, Herb Alpert, TLC, Sounds of Blackness, Yolanda Adams, Jordan Knight, Michael Jackson, Aretha Franklin, Boyz II Men, Usher, Johnny Gill, Patti LaBelle, Mary J. Blige, Chaka Khan, Mariah Carey, Prince, Mýa, Bryan Adams, Spice Girls, Vanessa Williams, George Michael, Melanie B, Rod Stewart, Kelly Price, Gwen Stefani, New Edition, Eric Benet, Pia Zadora, SOLO, and the Human League.In 1999, they produced the hit "Open My Heart" by Yolanda Adams which helped her popularity.

They have produced 16 Billboard Hot 100 No. 1 hits, and 26 Billboard R&B No. 1 hits.

They are among a handful of producers to have No. 1 records in three consecutive decades, with number ones in the 1980s, 1990s, and 2000s.

They have had 41 songs reach the Top 10 of the Billboard Hot 100,and 31 in the top 10 in the UK.

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