In this episode of the Scope of Things, host Deborah Borfitz brings you the latest news on AI-recommended precision dosing, organoid drug testing aiding treatment selection for bowel cancer, an AI tool for stratifying lung cancer patients, using HIV drugs to treat Alzheimer’s disease, and the potential value of magic mushrooms to remedy the mood symptoms of Parkinson’s. Blythe Adamson, international head of outcomes research and evidence generation at Flatiron Health, also joins in to discuss groundbreaking work harmonizing patient-level real-world data across four countries to enable multinational oncology research.  

News Roundup 

CURATE.AI platform 

• Article in Clinical Research News 
• Study in npj Precision Oncology   

FORECAST-2 clinical trial 

• News on the Walter and Eliza Hall Institute website 

AI tool for sorting cancer patients 

• Study in Nature Communications  

HIV drugs for Alzheimer’s protection 

• Study in Alzheimer’s & Dementia 

“Magic mushrooms” for Parkinson’s disease 

• Study in Neuropsychopharmacology 

Guest 

Blythe Adamson, Ph.D., international head of outcomes research and evidence generation at Flatiron Health  

• Flatiron Health enabling multinational oncology researh – article in Bio-IT World 

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 GUEST BIO 

Blythe Adamson, PhD, MPH, Head of Outcomes Research and Evidence Generation, International at Flatiron Health & Founder of Infectious Economics 
Dr. Blythe Adamson is the head of international outcomes research and evidence generation at Flatiron Health. 
 
As a visionary senior leader at Flatiron Health, her team pioneered deep learning language models for extraction of clinical details from EHR documents, breaking the limits of what was possible for humans to do alone. Learning from the experience of millions of patients with cancer, they generate evidence of treatment effectiveness and value used by governments around the world. Dr. Adamson co-invented a patented clinical decision-support tool, enabled by machine learning, that is used by cancer clinics to benefit patients. 
 
She holds degrees in microbiology, epidemiology, and pharmaceutical economics with a focus on infectious disease prevention. Dr. Adamson has held roles at the Bill and Melinda Gates Foundation Institute for Disease Modeling, the NIAID HIV Vaccine Trials Network, and Flatiron Health. 

The Scope of Things podcast explores clinical research and its possibilities, promise, and pitfalls. Clinical Research News senior writer, Deborah Borfitz, welcomes guests who are visionaries closest to the topics, but who can still see past their piece of the puzzle. Focusing on game-changing trends and out-of-the-box operational approaches in the clinical research field, the Scope of Things podcast is your no-nonsense, insider’s look at clinical research today.