Episode 34: Mapping Cancer's Blueprint: How Spatial Proteomics is Revolutionizing Detection
Description
In this episode of Concentrating on Chromatography, we sit down with Andreas Metousis, a PhD researcher at the Max Planck Institute of Biochemistry, to explore cutting-edge spatial proteomics and its role in understanding ovarian cancer development.Andreas discusses how Deep Visual Proteomics (DVP)—a method combining artificial intelligence, laser micro-dissection, and advanced mass spectrometry—is revolutionizing cancer research by providing unprecedented insight into the earliest molecular events in disease progression.Key Topics Covered:- How transcriptomics and proteomics differ and why both matter for cancer research- Deep Visual Proteomics (DVP): AI-driven cell identification and high-resolution protein analysis- Why high-throughput automation (384-well plates, EVOSEP, Thermo Fisher Orbital Astral Mass Spectrometer) is essential for modern proteomics- The IDO1 paradox: why an "immune evasion" protein actually protects cancer cells—and why that matters for failed clinical trials- Translating lab discoveries into real-world therapeutics: the drug development pipeline- Applying spatial proteomics beyond ovarian cancer (lung cancer, skin cancer, osteoarthritis, muscle biology)- Advice for students entering cancer research and academiaWhy This Matters:Andreas's work demonstrates how multi-modal omics integration and spatial resolution can identify novel drug targets and explain why some promising therapies fail in clinical practice. This episode bridges fundamental science with practical lab methodology and therapeutic impact.Perfect for: Analytical chemistry professionals, cancer researchers, graduate students, and anyone interested in how cutting-edge mass spectrometry and AI are transforming biomedical research.Spatial Proteomics, Mass Spectrometry, Ovarian Cancer, Deep Learning, AI in Science, Proteomics, Transcriptomics, Cancer Research, Drug Discovery, EVOSEP, Thermo Fisher Orbital Astral Mass Spectrometer, Laser Microdissection, IDO1, Immunotherapy, Analytical Chemistry
United States
