In this conversation, Dr. Caterina Minniti discusses curative therapies for sickle cell disease, focusing on gene therapy. She explains the process of preparing for gene therapy, including the discontinuation of hydroxyurea and the use of blood transfusions. Dr. Minniti also discusses the ideal patient for gene therapy, the timeline for the preparation process, and the manufacturing process of edited stem cells. She compares and contrasts gene therapy with stem cell transplantation and bone marrow transplantation, highlighting the potential complications and ongoing research in the field.

We are also joined by Genesis Jones. Genesis is a sickle cell warrior, survivor, advocate, student, and speaker, shares her journey with curative therapy. She discusses her life before the therapy, the motivation behind pursuing it, the challenges she faced during the transplant journey, and the concerns and side effects she experienced.