Episode 82 - Dr. Zac Spiritos breaks down what Mast Cell Activation Syndrome (MCAS) is and why it’s much more common than we think. Dr. Spiritos is a neurogastroenterologist known for connecting the dots between MCAS, POTS, hypermobility, gut dysfunction, and chronic unexplained symptoms. Together, we unpack why MCAS is so often missed, why it disproportionately affects women, and what it actually takes to begin feeling better.

If you’ve ever felt sensitive to everything; smells, foods, heat, medications, stress, and struggled with symptoms that seem to jump from system to system, this episode is one you don’t want to miss. Our conversation explores why MCAS is notoriously difficult to diagnose, including the lack of reliable biomarkers and the way symptoms wax and wane, organ-hop, and defy traditional medical algorithms. We also discuss the cultural and structural reasons MCAS is dismissed, especially in women, and why many patients are incorrectly labeled as anxious or psychosomatic.

Download & save Dr. Spiritos' MCAS handout here.

Connect with Zac on Instagram at @drzacspiritos or on his website at everbettermedicine.health.

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