In the fourth episode of METHYLOMIC matters our attention centers on a crucial element of METHYLOMIC: the development of an easy-to-use diagnostic test intended for clinical validation, with the ultimate aim of global adoption in medical centers. With Dr. Peter Henneman and Dr. Jules Petit we discuss the importance of a rapid assay and compare its pros and cons opposed to the current EPIC array methodology. All this and more in the fourth episode of METHYLOMIC matters!