Feasibility of high-resolution perfusion imaging using Arterial Spin Labelling MRI at 3 Tesla
Update: 2023-08-05
Description
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.08.02.551576v1?rss=1
Authors: Kashyap, S., Oliveira, I. A. F., Uludag, K.
Abstract:
Cerebral blood flow (CBF) is a critical physiological parameter of brain health, and it can be non-invasively measured with arterial spin labelling (ASL) MRI. In this study, we evaluated and optimized whole-brain, high-resolution ASL as an alternative to the low-resolution ASL employed in the routine assessment of CBF in both healthy participants and patients. Two high-resolution protocols (i.e., pCASL and FAIR-Q2TIPS (PASL) with 2 mm isotropic voxels) were compared to a default clinical pCASL protocol (3.4x3.4x4 mm3), all of whom had an acquisition time of {approx} 5 min. We assessed the impact of high-resolution acquisition on reducing partial voluming and improving sensitivity to the perfusion signal, and evaluated the effectiveness of z-deblurring on the ASL data. We compared the quality of whole-brain ASL acquired using three available head coils with differing numbers of receive channels (i.e., 20, 32, and 64 ch). In conclusion, this study demonstrates the feasibility of high-spatial resolution whole-brain ASL within the clinical scanning duration, offering higher spatial fidelity and resolving power than those obtained with current standard clinical ASL protocols.
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http://biorxiv.org/cgi/content/short/2023.08.02.551576v1?rss=1
Authors: Kashyap, S., Oliveira, I. A. F., Uludag, K.
Abstract:
Cerebral blood flow (CBF) is a critical physiological parameter of brain health, and it can be non-invasively measured with arterial spin labelling (ASL) MRI. In this study, we evaluated and optimized whole-brain, high-resolution ASL as an alternative to the low-resolution ASL employed in the routine assessment of CBF in both healthy participants and patients. Two high-resolution protocols (i.e., pCASL and FAIR-Q2TIPS (PASL) with 2 mm isotropic voxels) were compared to a default clinical pCASL protocol (3.4x3.4x4 mm3), all of whom had an acquisition time of {approx} 5 min. We assessed the impact of high-resolution acquisition on reducing partial voluming and improving sensitivity to the perfusion signal, and evaluated the effectiveness of z-deblurring on the ASL data. We compared the quality of whole-brain ASL acquired using three available head coils with differing numbers of receive channels (i.e., 20, 32, and 64 ch). In conclusion, this study demonstrates the feasibility of high-spatial resolution whole-brain ASL within the clinical scanning duration, offering higher spatial fidelity and resolving power than those obtained with current standard clinical ASL protocols.
Copy rights belong to original authors. Visit the link for more info
Podcast created by Paper Player, LLC
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