A quiet shift in one enzyme may be steering how we age—and how strong we stay. Dr. Helen Blau, trailblazing Stanford scientist and 2025 National Medal of Science honoree, joins us to unpack a breakthrough decades in the making: prostaglandin E2 is essential for muscle stem cell repair, yet a degrading enzyme creeps up with age, draining that signal and eroding strength. Her team calls it a “gerozyme,” and blocking it with a targeted small molecule restored muscle size, power, and endurance in aged mice. The first human safety trial is complete, and a Phase 2 study in sarcopenia is on deck.

We dig into the practical takeaways for athletes and anyone over 50: why the inflammatory wave after training is needed for rebuilding, how common NSAIDs can blunt the very gains you’re chasing, and where a future therapy might help overcome anabolic resistance after illness, injury, or bedrest. Dr. Blau connects the dots across regenerative medicine—tissue‑specific stem cells, iPSCs, and organoids—to show how disease can be modeled in a dish and how patient‑matched cells are speeding smarter drug discovery. We also touch on her early work proving cellular plasticity, new insights on telomeres shortening in heart cells without division, and what “quality” muscle means for safe aging.

Beyond the lab, we talk truth about unproven stem cell clinics, the progress and remaining gaps for women founders in biotech, and the urgent threat of research defunding that stalls clinical trials and drains the talent pipeline. There’s a clear throughline: if we want longer, stronger years—true health span—we need rigorous science, sustained support, and smart training habits that work with our biology, not against it.

If this conversation sparked a shift in how you think about aging and recovery, tap follow, share with a friend who lifts or runs, and leave a review. Your support helps bring evidence‑based breakthroughs to more people—and speeds the path from lab bench to everyday life.

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This BONUS EPISODE is our holiday gift for you! If you're looking for somewhere to offer a holiday or year end gift, please consider directly supporting scientists like Dr. Blau & their labs. Donations keep projects alive while funding is disrupted.

Dr. Blau: https://profiles.stanford.edu/helen-blau?tab=bio

The Lab: https://med.stanford.edu/blau-lab.html

The Book: https://www.amazon.com/Stem-Cells-Rescue-Helen-Blau/dp/1621825280

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