Genomic analysis of childhood tumours; biological and therapeutic implications
Update: 2017-07-31
Description
Dr Lichter speaks with ecancer at WIN 2017 about germline mutations and heritable predispositions behind in paediatric brain cancer.
He outlines the Sonic Hedgehog family of genes as common driver in medulloblastoma, and discusses how translocation of genes to enhancer regions can trigger disease onset.
Dr Lichter notes that guidelines for treatments must reflect mutational subtypes, with patients whose tumours show enhanced activation of Wnt-Catenin signalling among the best prognosis compared to APC and Sonic subtypes.
He outlines the Sonic Hedgehog family of genes as common driver in medulloblastoma, and discusses how translocation of genes to enhancer regions can trigger disease onset.
Dr Lichter notes that guidelines for treatments must reflect mutational subtypes, with patients whose tumours show enhanced activation of Wnt-Catenin signalling among the best prognosis compared to APC and Sonic subtypes.
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