In recent years, there has been increasing awareness of the important role mental health plays in our lives, as illustrated by the inclusion of mental health as a priority in the United Nations Sustainable Development Goals. Depression is one of the leading causes of disability. Suicide is the fourth leading cause of death among 15-29-year-olds. The COVID-19 pandemic only served to exacerbate existing mental health conditions, including among people living with HIV. Additionally, though, people living with mental health conditions often experience discrimination and stigma that pose barriers to accessing and utilizing evidence-based mental health interventions – cognitive and therapeutic. In this episode of HIV Connect we will explore the critical role of mental health in the lives of people living with HIV.