Dr. Todd Wills, Professor of Medicine with the Morsani College of Medicine at the University of South Florida, reviews the unique complications and issues that can occur in the elderly HIV patient. Dr. Wills begins by reviewing the epidemiology of HIV by age group, including the fact that the HIV positive population is growing older with time. Dr. Wills also discusses issues regarding polypharmacy and medication tolerability in the older patient. Next, the speaker relates how the high prevalence of chronic diseases affect the HIV positive patient’s prognosis. HIV positive elderly patients can suffer not just from frailty, but from cardiovascular disease, diabetes, osteoporosis, and cancer. Dementia can also affect an elderly HIV paitent’s overall wellness and compliance with antiviral therapy. Dr. Wills also covers the assessment of bone density in elderly HIV positive patients. Lastly, Dr. Wills discusses HIV positive patient life expectancy in the modern age of antiretroviral therapy. The lecture is updated for 2024.