Lifestyle risk factors, like poor sleep, social isolation, and a lack of exercise may have a significant impact on dementia risk. The best evidence tells us that if we make healthy changes to key lifestyle risk factors, we could reduce dementia cases worldwide by at least 45 per cent. On this episode, Defy Dementia hosts Jay Ingram and Dr. Allison Sekuler report back on their own brain-healthy resolutions – changes they tried in our own lives – and their learnings, trials, and tribulations. Plus, they share cutting-edge brain health news, some from the recent Alzheimer's Association International Conference 2025, on topics ranging from new drug trials and blood tests for detection, to a major lifestyle study, to the role of lithium in Alzheimer’s disease, to the potential impact of wildfire smoke exposure on dementia risk, to the shingles vaccine, and more. Tune in at defydementia.org, or anywhere you get your podcasts.