In this podcast our guest author is world renown Nephrologist, Dr. Robert Schrier of the University of Colorado School of Medicine, accompanied by one of eCysticFibrosis Review Program Directors, Dr. Mohamed Atta from the Johns Hopkins University School of Medicine. Dr. Schrier, describes the clinical implications of hyponatremia, evaluates the importance of the presence of symptoms and the rate of correction, and differentiate between acute and chronic disease, and summarizes the currently available approaches to treating hyponatremia.