LiverBOMB! A Deep Dive into Liver Failure
Description
We are joined once again by Michael Griggs PharmD, Dr. Taylor Wachs, and Will Appleby to discuss liver failure and its management and complications. We discuss everything from resuscitation management, pharmacology of course, and what are we really mitigating here.
Definition ALF - INR>1.5 with hepatic encephalopathy and no underlying cirrhosis
AST - Liver, cardiac, skeletal, kidney, brain, pancreas
ALT - SPECIFIC to liver damage
AST/ALT Ratio = 1 = Ischemia
AST/ALT Ratio > 2.5 = Alcoholism
AST/ALT Ratio < 1 = Viral, Ischemia, Toxic
HRS = Hepatorenal Syndrome
NAC (Mucomyst)
Tylenol Dosing - 150mg/kg over 1 hour, 50 mg/kg over 4 hour
ALF mitigating transplant - 150mg/kg over 15 min, 12.5mg/kg/hr for 4 hours then 6.25 mg/kg/hr for 72 hours
United States
