The 2025/26 NFL Season is underway, and we have all of our picks and predictions for Week 1. Eddie doubles down on the Kansas City Chiefs to struggle, but expects the heavy favorites to get off to a hot start. The Bengals, Broncos, Cardinals, and Commanders all have nice matchups to start the season, but does Frank believe that the New York Giants can carry their good preseason form over into the regular season?

Plus, there are already injury concerns for the San Francisco 49ers, key divisional matchups in the AFC and NFC, and Josh Allen and Lamar Jackson go head-to-head in one of the best Sunday Night Football games of the season.