Non-linear Elimination and Dosage Regimen

Update: 2006-09-17

Description

For drugs which exhibit non-linear metabolism within their therapeutic range can be difficult to dose. Small changes in dose can result in larger changes in concentration. Using average values for parameters can be a good start but better results can be achieved with therapeutic drug monitoring. Analysis of TDM data can by use of equations or graphical methods. Both types of approaches are described in this tutorial.

Comments

In Channel

Non-linear Elimination and Dosage Regimen

2006-09-1704:56

Calculating a multiple dose IV regimen

2006-02-2604:46

Analysis of Urine Data - audio

2006-02-1403:37

Analyzing IV Infusion Data

2006-02-1302:44

Analysis of Urine Data

2006-02-1303:37

Writing DEs - audio

2006-02-0706:01

Writing DEs

2006-02-0706:01

Superposition Principle - audio

2006-01-2303:42

Superposition Principle

2006-01-2303:40

Calculating a multiple dose IV regimen 2

2006-01-2205:11

Calculating a multiple dose IV regimen 2 - audio

2006-01-2205:14

Calculating kel and V

2006-01-1703:02

Calculating a multiple dose IV regimen - audio

2006-01-1704:46

Method of Residuals

2006-01-1605:32

Calculating AUC

2006-01-1602:20

Graphing Data

2006-01-1603:27

Calculating AUC - audio

2006-01-0504:46

Calculating kel and V - audio

2006-01-0503:02

Analyzing IV Infusion Data - audio

2006-01-0502:44

Method of Residuals - audio

2006-01-0505:32

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Non-linear Elimination and Dosage Regimen

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Non-linear Elimination and Dosage Regimen

David Bourne

Non-linear Elimination and Dosage Regimen