Today’s conversation with my guest Ashwell Glasson gives provides us with a view of the scale and scope of the challenges we are facing in securing biodiversity. What is being called for is an overhaul of the current models and mindsets driving conservation efforts in global landscapes under multiple pressures, including transnational wildlife crime at unprecedented levels. For the sake of frame of reference, our discussion is focused on rhino conservation as it holds markers of all that is changing and is at stake. The conversation takes multiple twists and turns as we unravel layers and identify the players toward a new world vision that can redefine the benchmark of health and wealth in passing the torch to new generations. Rather than a revision of what doesn’t work; solutions that resonate and engender cross-cultural participation at all levels of society, are augmented with new tool kits and skillsets for a holistic–earth one-health operating system.