In the second episode of METHYLOMIC matters we have the privilege of conversing with Professor Geert D’Haens and Dr. Andrew Li Yim as we delve into the pre-METHYLOMIC era and discover the science behind the OMICROHN trial: the EPIC-CD study. How did we design this biomarker discovery study and what are key important methodological steps? What were the main results and how do we envision the future? All this and more in the second episode of METHYLOMIC matters!