In the episode, Dr. Carol Ann Remme (University of Amsterdam) and Dr. Sadis Matalon (University of Alabama Birmingham) interview Dr. Jenny Van Eyk (Cedars-Sinai) about the Review in Physiological Reviews by Karpov et al. that dives into proteomics of the heart. Given that proteins are the building blocks of life, studying only genetic data or RNAseq data may offer researchers a somewhat narrow view. Proteomics looks broader, and broader is better, according to Dr. Van Eyk. However, this means that rigor at the proteomic technology level is critically important. Because the field of proteomics offers many different tools, using proteomics to study the heart necessitates matching the research question to the right tool. Dr. Van Eyk encourages researchers to develop a well-defined research question and then match it to the proteomics technology that is most appropriate, so that the output is as useful as possible. Pushing research to new frontiers allows researchers to find discoveries they never expected. Listen now and learn more.

Oleg A. Karpov, Aleksandr Stotland, Koen Raedschelders, Blandine Chazarin, Lizhuo Ai, Christopher I. Murray, Jennifer E. Van Eyk Proteomics of the Heart Physiological Reviews, published April 9, 2024. DOI: doi.org/10.1152/physrev.00026.2023