The Reason Interview with Nick Gillespie goes deep with the artists, entrepreneurs, politicians, and visionaries who are making the 21st century more libertarian—or at least more interesting—by challenging worn-out ideas and orthodoxies.

Today's guest is Joe Dolce, whose new book is Modern Psychedelics: The Handbook for Mindful Exploration.

Dolce argues that psychedelics aren't just the province of hippies or tech bros anymore. They are powerful and increasingly popular—and legal—tools for therapy, self-discovery, and play.

He talks with Gillespie about everything from the misunderstood role of ketamine in Friends star Matthew Perry's death to why ibogaine may be the only substance on Earth that can stop addiction cold, to how we went from "Just Say No!" campaigns to mail-order magic mushrooms in just a few short decades.

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0:00 —Intro

1:25 —What do psychedelics teach?

7:02 —Psychedelic safety and ketamine myths

13:01 —How psychedelics work and ibogaine effects

19:12 —Microdosing

23:00 —Psychedelics and altered states

28:10 —Generational perceptions of psychedelics

30:59 —Cultural acceptance of psychedelics

42:22 —The future of psychedelics

48:34 —Drug legalization and access

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