On today’s episode we discuss the latest hot topic in the fitness industry - weight loss drug, Retatrutide.

What are the benefits? Are there potential side effects? What does this mean for bikini competitors in prep, dieting hard for a show?

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Key references

• Jastreboff AM, et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity. N Engl J Med / related publications (phase-2 reports).

• Sanyal AJ, et al. Retatrutide and liver fat/liver outcomes. Nature Medicine 2024.

• Wilding JPH, et al. Once-weekly semaglutide in adults with overweight or obesity (STEP). N Engl J Med 2021.

• Jastreboff AM, et al. Tirzepatide once weekly for obesity (SURMOUNT) and related reports. PubMed/NEJM/SURMOUNT analyses.

• Conceição-Furber E, et al. Is glucagon receptor activation the thermogenic solution? Frontiers in Endocrinology, review of GCGR and energy expenditure mechanisms.

• Frampton J, et al. The acute effect of glucagon on components of energy expenditure. Int J Obes / Nature Metabolism meta-