This episode synthesizes key information from provided sources on adult peripheral nerve disorders and brachial plexus injuries, focusing on pathophysiology, diagnosis, treatment options, and outcomes. Peripheral nerve disorders encompass a wide spectrum, from entrapment neuropathies to severe traumatic injuries like brachial plexus avulsion. Accurate diagnosis relies on a detailed history, meticulous clinical examination, and advanced electrophysiologic and radiographic studies. Treatment goals include pain management and restoration of sensory and motor function, often involving complex surgical interventions such as direct nerve repair, nerve grafting, and nerve transfers. Recent advancements, particularly in nerve transfer techniques and the use of allografts, offer promising alternatives to traditional methods, aiming for faster and more effective recovery while minimizing donor-site morbidity. However, challenges remain, especially for extensive injuries and in the context of chronic pain.

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Citations

1. Fox IK, Mackinnon SE. Adult Peripheral Nerve Disorders: Nerve Entrapment, Repair, Transfer, and Brachial Plexus Disorders. Plast Reconstr Surg. 2011;127(5S):105e–118e. doi:10.1097/PRS.0b013e31820cf556.

2. Terzis JK, Kostopoulos VK. The Surgical Treatment of Brachial Plexus Injuries in Adults. Plast Reconstr Surg. 2007;119(4):73e–92e. doi:10.1097/01.prs.0000254859.51903.97.

3. Leckenby JI, et al. Outcomes of Avance Nerve Allografts. Plast Reconstr Surg. 2020;145(2):368e–380e. doi:10.1097/PRS.0000000000006485.

4. Safa B, et al. Recovery of Motor Function after Mixed and Motor Nerve Repair with Processed Nerve Allograft. PRS Global Open. 2019;7:e2163. doi:10.1097/GOX.0000000000002163.

Disclaimer

Educational only; not medical advice or a substitute for reading the full studies or clinical judgment.