S1E6 - Going Retro to Tackle Confounding: Assessing Risk of SBP from PPI use in Cirrhosis
Update: 2023-08-11
Description
Welcome to What's it Worth! Join your hosts, Dr. Diana Langworthy & Garrison Griest as we go retro to tackle confounding variables! We'll be reviewing an article that aimed to determine the risk of spontaneous bacterial peritonitis (SBP) in patients with cirrhosis who are using proton pump inhibitors (PPIs).
Key Points
- Retrospective studies produce more opportunities for confounding variables to impact study results
- Proton pump inhibitors are widely used and overused for acid reflux disease and have been associated with several risks
- Odds ratios calculated for retrospective cohort studies determine associations between an intervention and a risk
- How much confouding is too much? --> Tune in to find out!
References
- [EPISODE TRIAL] Dahabra L, Kreidieh M, Abureesh M, et al. Proton pump inhibitor use and increased risk of spontaneous bacterial peritonitis in chrrhotic patients: A retrospective cohort analysis. Gastroenterol Res. 2022;15(4):180-187.
- Biggins SW, Angeli P, Garcia-Tsao G, et al. Diagnosis, evaluation and management of ascites, spontaneous bacterial peritonitis and hepatorenal syndrome: 2021 practice guidance by the American Association for the Study of Liver Diseases. Hepatology.2021;74(2)1014-1048
Contact Information
Podcast email: whatsitworthpodcast@gmail.com
Host Information
Dr. Diana R. Langworthy, PharmD, BCPS
Clinical Associate Professor, University of Minnesota College of Pharmacy
Clinical Pharmacist - Inpatient Internal Medicine, M Health Fairview East Bank Hospital
Guest Host Information
Garrison Griest, Student Pharmacist, Class of 2025 University of Minnesota
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