Could NfL and GFAP redefine how clinicians track progression in MS? Dr Mark Freedman joins Dr Anne Cross to explain the evolving science behind these powerful biomarkers.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002608. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Multiple Sclerosis https://emedicine.medscape.com/article/1146199-overview

Fluid Biomarkers in Multiple Sclerosis: From Current to Future Applications https://pubmed.ncbi.nlm.nih.gov/39444698/

National Hospital for Neurology and Neurosurgery https://www.uclh.nhs.uk/our-services/our-hospitals/national-hospital-neurology-and-neurosurgery

Neurofilament Biophysics: From Structure to Biomechanics https://pubmed.ncbi.nlm.nih.gov/38598299/

Glymphatic System: An Emerging Therapeutic Approach for Neurological Disorders https://pubmed.ncbi.nlm.nih.gov/37485040/

Axonal Transection in the Lesions of Multiple Sclerosis https://pubmed.ncbi.nlm.nih.gov/9445407/

The Combination of CSF Neurofilament Light Chain and Glial Fibrillary Acidic Protein Improves the Prediction of Long-Term Confirmed Disability Worsening in Multiple Sclerosis https://pubmed.ncbi.nlm.nih.gov/39587121/

Amit Bar-Or, MD https://www.med.upenn.edu/apps/faculty/index.php/g324/p8937426

Anxiety, Depression, and Expanded Disability Status Scale Independently Predict the Perception of Disability in Persons With Multiple Sclerosis: A Cross-Sectional Study https://pubmed.ncbi.nlm.nih.gov/39839740/

Diagnosis of Multiple Sclerosis: 2024 Revisions of the McDonald Criteria https://pubmed.ncbi.nlm.nih.gov/40975101/

Radiologically Isolated Syndrome: A 6-Year Follow-Up Study in Chile https://pubmed.ncbi.nlm.nih.gov/40120160/

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: Current Insights Into the Disease Pathophysiology, Diagnosis and Management https://pubmed.ncbi.nlm.nih.gov/33374173/