SLU-PP-332: The Breakthrough “Exercise in a Pill” Peptide for Energy, Metabolism, and Longevity
Update: 2025-10-29
Description
In this episode of Ageless Future, Regan Archibald explores the groundbreaking molecule SLU-PP-332, a compound designed to mimic the metabolic benefits of exercise by activating key genetic and mitochondrial pathways. Originally developed by researchers at St. Louis University, SLU-PP-332 works through the ERR-alpha and AMPK pathways, promoting fat oxidation, mitochondrial biogenesis, and improved insulin sensitivity—without the oxidative stress of overtraining. Regan discusses how animal studies demonstrated dramatic improvements in endurance, fat loss, and glucose control, and shares his own experience using SLU-PP-332 to enhance VO₂ max, energy, and recovery. He also outlines its potential applications for metabolic syndrome, muscle loss, inflammation, and even post-COVID mitochondrial dysfunction. The episode concludes with practical insights on stacking SLU-PP-332 with other peptides like MOTS-c, 5-Amino-1MQ, and BPC-157 for comprehensive metabolic rejuvenation, while emphasizing the foundation of longevity medicine: optimizing insulin sensitivity, mitochondrial efficiency, and consistent physical conditioning.
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