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Sam Altman makes his second appearance on the show to discuss how he's managing OpenAI's explosive growth, what he's learned about hiring hardware people, what makes roon special, how far they are from an AI-driven replacement to Slack, what GPT-6 might enable for scientific research, when we'll see entire divisions of companies run mostly by AI, what he looks for in hires to gauge their AI-resistance, how OpenAI is thinking about commerce, whether GPT-6 will write great poetry, why energy is the binding constraint to chip-building and where it'll come from, his updated plan for how he'd revitalize St. Louis, why he's not worried about teaching normies to use AI, what will happen to the price of healthcare and hosing, his evolving views on freedom of expression, why accidental AI persuasion worries him more than intentional takeover, the question he posed to the Dalai Lama about superintelligence, and more.

Recorded live at the Progress Conference, hosted by the Roots of Progress Institute. Special thanks to Big Think for the video production.

Read a full transcript enhanced with helpful links, or watch the full video on the new dedicated Conversations with Tyler channel.

Recorded October 17th, 2025.

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Photo Credit: Jeremi Rebecca