Testing to treatment of BRAF-mutant metastatic NSCLC 

In this educational podcast episode, experts Prof. David Planchard and Dr Federico Cappuzzo discuss the significance of BRAF mutations in metastatic non-small cell lung cancer (NSCLC), the testing strategies and first- and second-line treatment options for these patients.  

The discussion focuses on which BRAF mutations to test for and when in the patient journey to test, before moving on to consider if NGS broad panel testing should be applied routinely for patients.  Various treatments are considered, along with which decision criteria come into play when selecting a particular treatment.  

The experts also discuss how to treat patients who have co-mutations detected during testing. 

This is an informative podcast that culminates in some interesting key messages from two well-recognised Experts in the field of NSCLC. 

Key clinical takeaways:  

• Test all patients irrespective of histology and smoking history 

• Test upfront so that more efficacious agents can be used earlier in the patient journey 

• Next-generation sequencing is the gold-standard for testing wherever possible to ensure various targetable alterations are not missed 

• There are effective BRAF + MEK inhibitor combination treatments available to treat our BRAFv600E-mutant metastatic NSCLC patients which have manageable safety profiles 

Would you prefer to watch the experts in conversation? This podcast episode is also available in video format, here: https://youtu.be/UZPBUAFOwcY

Download the trasncript and find out more about this programme and the featured experts here: https://cor2ed.com/lung-connect/programmes/testing-treatment-braf-mutant-metastatic-nsclc/

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This content is intended for healthcare professionals outside of the UK only.  

The medical experts in this podcast are expressing their own views and not those of COR2ED, Supporters or their institution.  This podcast is supported by an Independent Education Grant from Pierre Fabre 

This podcast is developed by https://cor2ed.com/ 

Published November 2024 

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