In the first episode, Bob Kevoian discusses his cancer diagnosis and treatment journey, with the support of his wife Becky and friend Whit Grayson. They discuss the initial shock and numbness that came with the diagnosis. Despite the tough news, they commend the efficient team of physicians who quickly mapped out a plan and helped them understand the process to come. Bob remains optimistic about fighting the cancer and hopes to document his progress for listeners who may be experiencing the same fear and uncertainty.