DiscoverCurie: The Oncology BriefThe Changing Landscape of Rectal Cancer Treatment
The Changing Landscape of Rectal Cancer Treatment

The Changing Landscape of Rectal Cancer Treatment

Update: 2025-03-21
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Curie is your personalized, expert-driven healthcare podcast platform—offering in-depth analysis, timely insights, and discussions tailored for medical professionals.

Dr. Goldfarb, your request led us to this deep dive into the evolving treatment landscape of rectal cancer. In this episode of Ask Curie, we explore non-operative management strategies, the role of immunotherapy, and how biomarker-driven care is transforming clinical decision-making. We break down key findings, including the growing viability of the “watch-and-wait” approach, short-course vs. long-course radiation therapy, and emerging targeted therapies like checkpoint inhibitors for MSI-high tumors. Should oncologists be reconsidering surgery-first approaches? And what does the latest data say about de-escalating treatment without compromising outcomes? Tune in for an evidence-based look at the future of rectal cancer treatment.

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The Changing Landscape of Rectal Cancer Treatment

The Changing Landscape of Rectal Cancer Treatment