The I-70 killer is an unidentified American serial killer who is known to have killed six store clerks in the Midwest in the spring of 1992. His nickname derives from the fact that several of the stores in which his victims worked were located a few miles off of Interstate 70 (I-70).

His victims were usually young, petite, brunette women. One of the victims was a man, but it is believed that the killer may have expected a woman in the store due to the store having a woman's name. All of the stores attacked were specialty stores and were usually only robbed of small amounts of cash.[1] He is also suspected of shooting three more store clerks in Texas during 1993 and 1994, one of whom survived, as well as a 2001 murder of a store clerk in Terre Haute, Indiana.

Despite the case being featured on Unsolved Mysteries, America's Most Wanted, and Dark Minds, the killer is yet to be identified and investigators have not publicly identified any suspects.