The Lead Episode 123: A Discussion of Re-Ablation of Atrial Fibrillation Targeting Electrogram Dispersion –The RESTART Trial, Live at HRX 2025
Description
Join host and HRS Digital Education Committee Vice-Chair, Tina Baykaner, MD, MPH and her guests Jerome Kalifa, MD and Paul C. Zei, MD, PhD, FHRS as they discuss this article at HRX 2025 in Atlanta.
The RESTART trial is an international, multicenter, non-randomized interventional study designed to assess whether using Volta Medical's AI-assisted algorithm to identify and ablate dispersed electrograms (EGMs) in addition to doing repeat pulmonary vein isolation can improve outcomes in patients whose atrial fibrillation recurred after previous ablations.The main goal is to see the proportion of patients who are free from AF twelve months after the repeat procedure (without antiarrhythmic drugs), and the trial contains about 92 patients.
Learning Objective
Describe the design and purpose of the RESTART trial, including how the use of AI-guided identification and ablation of dispersed electrograms aims to improve outcomes for patients undergoing repeat ablation for recurrent atrial fibrillation.
Article Authors
- John D. Hummel
- Haroon Rachid
- Isabel Deisenhofer
- Paul C. Zei
- Gustavo Morales
- Jerome Horvilleur
- Stavros Mountantonakis
- Jean-Paul Albenque
- Devi G. Nair
- Benjamin D'Souza
- Smit C. Vasaiwala
- Tom De Potter
- Daniel H. Cooper
- Mark Metzl
- Adi Lador
- Anthony R. Magnano
- Alexandru B. Chicos
- Joshua R. Silverstein
- Daniel Guerrero
- Shirley Beguin
- Anas El-Benna
- Sabine Lotteau
- Marie-Sophie Nguyen-Tu
- Paola Milpied
- Jerome Kalifa
- Bradley P. Knight
- Dhanunjaya R. Lakkireddy
Podcast Contributors
Jerome Kalifa, MD
Paul C. Zei, MD, PhD, FHRS
Tina Baykaner, MD, MPH
All relevant financial relationships have been mitigated.
Host Disclosure(s):
T. Baykaner
•Honoraria/Speaking/Consulting: Volta Medical, Medtronic, Pacemate, Johnson and Johnson, Abbot Medical, Boston Scientific
Contributor Disclosure(s):
J. Kalifa:
P. Zei
•Research: Biosense Webster, Inc.
Staff Disclosure(s) (note: HRS staff are NOT in control of educational content. Disclosures are provided solely for full transparency to the learner):
S. Sailor: No relevant financial relationships with ineligible companies to disclose.
United States
