DiscoverDDT Method PodcastThe Mitochondria Enhancement Debate! - with Alex Kikel and Anthony Castore
The Mitochondria Enhancement Debate! - with Alex Kikel and Anthony Castore

The Mitochondria Enhancement Debate! - with Alex Kikel and Anthony Castore

Update: 2025-07-28
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TOP TAKEAWAYS:

  • Why combining BAM15 + SLU-PP-332 could be sabotaging your results
  • The "start low, go slow" protocol that prevents mitochondrial damage
  • How to structure fasting + refeed cycles for maximum fat loss
  • Advanced supplementation strategies for 40+ professionals
  • The critical difference between structure and function optimization


In this landmark 2-hour debate, mitochondrial experts Anthony Castore and Alex Kikel dive deep into the controversial combination of BAM15 and SLU-PP-332. This isn't your typical supplement discussion – it's a masterclass in advanced optimization for experienced athletes and high-performing professionals.

This episode breaks down the complex world of mitochondrial enhancement, covering everything from basic cellular structure to cutting-edge peptide protocols. Anthony and Alex present different perspectives on combining these powerful compounds, with one advocating for separation and strategic timing, while the other supports careful low-dose combination approaches.

CHAPTER BREAKDOWN:

  • Mitochondrial Membrane Potential & Hyperpolarization
  • The Structure-Function Relationship in Cellular Optimization
  • BAM15: Uncoupling for Fat Loss and Cognitive Enhancement
  • SLU-PP-332: PGC1-Alpha Activation and Mitochondrial Biogenesis
  • Combination Protocols: Benefits vs. Risks
  • Advanced Fasting + Refeed Strategies
  • Supporting Supplement Stacks for Maximum Safety
  • Real-World Application for Different Populations


KEY PROTOCOLS DISCUSSED:

  • 24-hour fast to refeed optimization sequence
  • Training day vs. rest day compound timing
  • Dosage titration strategies (100mcg-50mg ranges)
  • Biomarker tracking for safety monitoring
  • Polypharmacy considerations for TRT users


IMPORTANT DISCLAIMER: This content is for educational purposes only. These are research compounds without human safety studies. Always consult healthcare professionals before implementing any protocols discussed.

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The Mitochondria Enhancement Debate! - with Alex Kikel and Anthony Castore

The Mitochondria Enhancement Debate! - with Alex Kikel and Anthony Castore

Drew Donaldson